磷酸化白细胞介素1受体衔接蛋白抗体 phospho-TIRAP(Tyr86)

磷酸化白细胞介素1受体衔接蛋白抗体 phospho-TIRAP(Tyr86)
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产品价格: < 面议
产品型号:phospho-TIRAP(Tyr86)
 牌:单克隆抗体/多克隆抗体
公司名称:上海信裕生物技术有限公司
  地:上海松江
发布时间:2018-08-10
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产品简介

磷酸化白细胞介素1受体衔接蛋白抗体应用于IHC、WB、 IF、IP、ELISA等科研实验,按理化性质和生物学功能IgM、IgG、IgA、IgE、IgD五类。按抗体的来源,可将其分为天然抗体和免疫抗体。磷酸化白细胞介素1受体衔接蛋白抗体生产每个流程都执行严格的检测标准,保证蛋白抗原产品质量,质量稳定,实验效果明显。

产品详细信息

磷酸化白细胞介素1受体衔接蛋白抗体

规格:1mg/1ml

英文名: phospho-TIRAP(Tyr86)

别名: TIRAP (phospho Y86); Adapter protein wyatt; MAL antibody MyD88 adapter like protein; TIR domain containing adapter protein; Toll interleukin 1 receptor (TIR) domain containing adaptor protein; Toll in

分子量: 24kDa

储存液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆类型:Polyclonal

亚型:IgG

纯化方法:affinity purified by Protein A

免疫原:KLH conjugated Synthesised acetylpeptide derived from human

交叉反应:Human, Mouse, Dog, Pig, Cow, Horse, Guinea Pig,

细胞定位:细胞浆

磷酸化白细胞介素1受体衔接蛋白抗体产品介绍:background: The Toll-like receptor (TLR) family in mammals comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules. The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. Ten human homologs of TLRs (TLR1-10) have been described. TIRAP (TIR domain-containing adaptor protein) is an adaptor protein used by TLR4. Blocking TIRAP inhibits TLR4-mediated signaling events, including DC maturation and cytokine production. Function: Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6. Subunit: Homodimer. Also forms heterodimers with MyD88. Binds to 磷酸化白细胞介素1受体衔接蛋白抗体TLR4 and IRAK2 via their respective TIR domains. Binds to BMX, PKR and TBK1. Does not interact with IRAK1, nor TLR9. Subcellular Location: Cytoplasm. Tissue Specificity: Highly expressed in liver, kidney, spleen, skeletal muscle and heart. Also detected in peripheral blood leukocytes, lung, placenta, small intestine, thymus, colon and brain. Post-translational modifications: Phosphorylated by IRAK1 and IRAK4. Also phosphorylated by BTK. Polyubiquitinated. Polyubiquitination follows phosphorylation by BTK and leads to TIRAP degradation. Similarity: Contains 1 TIR磷酸化白细胞介素1受体衔接蛋白抗体 domain. Gene ID: 114609 Database links: Entrez Gene: 114609 Human Entrez Gene: 117149 Mouse Entrez Gene: 680127 Rat GenBank: AF378129 Human GenBank: AF378130 Human Omim: 606252 Human SwissProt: P58753 Human SwissProt: Q99JY1 Mouse Unigene: 537126 Human Unigene: 23987 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

磷酸化白细胞介素1受体衔接蛋白抗体产品应用:WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域:心血管  细胞生物  免疫学  信号转导  

储存条件: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

来源: Rabbit

外观: Lyophilized or Liquid




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