细胞分裂周期相关蛋白5抗体 CDCA5

细胞分裂周期相关蛋白5抗体 CDCA5
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产品价格: < 面议
产品型号:CDCA5
 牌:单克隆抗体/多克隆抗体
公司名称:上海信裕生物技术有限公司
  地:上海松江
发布时间:2018-08-10
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产品简介

细胞分裂周期相关蛋白5抗体应用于IHC、WB、 IF、IP、ELISA等科研实验,按理化性质和生物学功能IgM、IgG、IgA、IgE、IgD五类。按抗体的来源,可将其分为天然抗体和免疫抗体。细胞分裂周期相关蛋白5抗体生产每个流程都执行严格的检测标准,保证蛋白抗原产品质量,质量稳定,实验效果明显。

产品详细信息

mg平台送彩金 mg注册送38体验金 mg注册直接送体验金

规格:1mg/1ml

英文名: CDCA5

别名: Cell division cycle associated protein 5; MGC16386; p35; Sororin; CDCA5_HUMAN.

分子量: 28kDa

储存液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆类型:Polyclonal

亚型:IgG

纯化方法:affinity purified by Protein A

免疫原:KLH conjugated synthetic peptide derived from human CDCA5

交叉反应:Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,

细胞定位:细胞核

mg平台送彩金 mg注册送38体验金 mg注册直接送体验金 产品介绍:background: Sororin, also designated cell division cycle-associated protein 5 (CDCA5) or p35, functions as a regulator of sister chromatid cohesion during mitosis. It interacts with the APC/C complex and is found in a complex consisting of cohesion components SCC-112, MC1L1, SMC3L1, RAD21 and APRIN. The deduced human and mouse Sororin proteins consist of 252 and 264 amino acid residues, respectively, and both contain a KEN box for APC-dependent ubiquitination. Reserach demonstrates a punctated nuclear distribution of Sororin during interphase and a diffuse distribution throughout the cell during mitosis. There is no apparent concentration of Sororin on chromatin in mitotic cells and Sororin levels decrease in synchronized HeLa cells during interphase. The Sororin gene maps to chromosome 11q12.1. Function: CDCA5 is a regulator of sister chromatid cohesion in mitosis. It may act by regulating the ability of the cohesin complex to mediate sister chromatid cohesion, perhaps by altering the nature of the interaction of cohesin with the chromosomes. CDCA5 interacts with the APC/C complex and is found in a complex with the cohesin components SMC1L1, SMC3L1, RAD21, PDS5A/APRIN and PDS5B/SCC-112. Subunit: Interacts with the APC/C mg平台送彩金 mg注册送38体验金 mg注册直接送体验金 complex (By similarity). Interacts with the chromatin-bound cohesin complex; the interaction is indirect, occurs after DNA replication and requires acetylation of the cohesin component SMC3. Interacts (via the FGF motif) with PDS5A and PDS5B; the interaction is direct and prevents the interaction of PDS5A with WAPAL. Subcellular Location: Nuclear. Post-translational modifications: Phosphorylated. Phosphorylation, as cells enter mitosis, disrupts the interaction with PDS5A and relieves the inhibition of WAPAL by CDCA5. Ubiquitinated by the APC/C complex in G1mg平台送彩金 mg注册送38体验金 mg注册直接送体验金 , leading to its degradation (Probable). Similarity: Belongs to the sororin family. Database links: UniProtKB/Swiss-Prot: Q96FF9.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

mg平台送彩金 mg注册送38体验金 mg注册直接送体验金 产品应用:WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域:细胞生物  染色质和核信号  细胞周期蛋白  细胞分化  表观遗传学  

储存条件: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

来源: Rabbit

外观: Lyophilized or Liquid




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